Abstract #2093

In-Vivo Quantification of Aortic Stiffness in Abdominal Aortic Aneurysm Porcine Model using Magnetic Resonance Elastography: A Comparison to Histopathology and Burst Testing

Huiming Dong^1,2, Duncan Russell³, Xiaokui Molly Mo⁴, Matthew Joseph⁵, Prateek Kalra¹, Richard White^1,6, and Arunark Kolipaka^1,2,6

¹Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ²Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ³Department of Biomedical Sciences, Oregon State University, Corvallis, OR, United States, ⁴Center for Biostatistics, The Ohio State University, Columbus, OH, United States, ⁵Davis Heart & Lung Research Institute-Interventional Cardiology Cath Core Lab, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁶Internal Medicine-Cardiovascular Division, The Ohio State University Wexner Medical Center, Columbus, OH, United States

Aortic stiffness is an important biomarker that can provide more accurate rupture potential of abdominal aortic aneurysm (AAA) than diameter. Aortic MR elastography (AMRE) is a non-invasive technique to estimate aortic stiffness and has not been validated against gold standard methods. The aim of the study is to estimate aortic stiffness in AAA-induced porcine model using in-vivo AMRE, and compare it with histopathology and burst testing. Results demonstrated that AAA stiffness was significantly higher than normal aorta (p<0.002), while %elastin and burst pressure was significantly lower in AAA (p<0.0001). Aortic stiffness showed significant negative correlation to %elastin and burst pressure.

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