Abstract #2080

Plaque permeability assessed with dynamic contrast-enhanced MRI predicts ferumoxytol nanoparticle delivery in patients with peripheral artery disease

Kang H. Zheng¹, Jasper Schoormans², Lotte Stiekema¹, Claudia Calcagno³, Iwona Cicha⁴, Aart J Nederveen⁵, Gustav J Strijkers², Erik S.G. Stroes¹, and Bram F Coolen²

¹Department of Vascular Medicine, Amsterdam UMC, Amsterdam, Netherlands, ²Department of Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam, Netherlands, ³TMII, Icahn School of Medicine, New York, NY, United States, ⁴University Hospital Erlangen, Erlangen, Germany, ⁵Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands

We investigated whether dynamic-contrast enhanced (DCE-)MRI could be used to predict accumulation of ferumoxytol nanoparticles in femoral plaques. To this end, we implemented USPIO enhanced quantitative T2* imaging, as well as 3D black-blood DCE-MRI sequences for femoral artery vessel wall imaging. Patients with peripheral artery disease (PAD) and healthy volunteers were included in this study. We show that ferumoxytol nanoparticle delivery to atherosclerotic plaques is associated with plaque permeability as assessed with DCE-MRI in patients with PAD.

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