The Zucker Diabetic Fatty (ZDF) rat is a well-known hyperinsulinaemic and hyperlipidaemic model of severe uncompensated Type 2 diabetes (T2DM) that displays systolic cardiac dysfunction late in life at the 40 week timepoint. Hyperpolarized Magnetic Resonance (MR) is a new medical imaging technique that can provide a novel way to probe metabolism in vivo and has been widely used to demonstrate physiological and pathological changes in pyruvate metabolism in the rodent heart. This work presents a magnetic resonance characterisation of the ZDF rat with hyperpolarized MR that detects metabolic alterations prior to the development of cardiac dysfunction.
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