Abstract #2030

Novel phase-sensitive late gadolinium enhancement MRI for assessment of myocardial infarction in large animals

Anna V Naumova¹, Niranjan Balu¹, Hiroshi Tsuchida^2,3, Lauren E Neidig^2,3,4, RS Thies^2,3, Charles E Murry^2,3, and Chun Yuan¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Pathology, University of Washington, Seattle, WA, United States, ³Institute for Stem Cells and Regenerative Medicine, University of Washington, Seattle, WA, United States, ⁴Comparative Medicine, University of Washiington, Seattle, WA, United States

Novel phase sensitive reconstruction method of the gadolinium delayed hyperenhancement, 3D-TRIPS, was used for the first time in the infarct visualization and quantitation in the hearts of non-human primates and Yucatan mini-pigs. Advantages of using 3D-TRIPS reconstruction vs. standard 2D-PSIR method for MR imaging of infarct include scan time shortening due to elimination the background phase-reference scan and improvement of the contrast ratio between normal and infarcted myocardium as well as between scar and blood. The novel cardiac MRI 3D-TRIPS method provides robust infarct size measurements while preserving scan time.

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