Abstract #1949

Simultaneous Assessment of Hyperpolarized [1-13C]Lactate and [13C]Bicarbonate with Fly-Back Echo Planar Imaging

Junjie Ma¹, Edward P. Hackett¹, Rolf F. Schulte², and Jae Mo Park^1,3,4

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²GE Healthcare, Munich, Germany, ³Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Electrical Engineering, UT Dallas, Dallas, TX, United States

In this study, we designed a spectral-spatial radiofrequency pulse that excites hyperpolarized [¹³C]bicarbonate and [1-¹³C]lactate peaks simultaneously while suppressing [1-¹³C]alanine, [1-¹³C]pyruvate and [1-¹³C]pyruvate hydrate signal. In combination with multi-shot fly-back echo planar imaging readout, the excited bicarbonate and lactate images can be spatially separated with an appropriate echo-spacing. The proposed method was validated by a phantom study, and tested in vivo using healthy Wistar rats with hyperpolarized [1-¹³C]pyruvate.

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