By identifying quantitative marker of ectopic pancreatic fat and volume clinicians may be able to screen for insulin resistance and offer early intervention. In this retrospective pilot case-control study, ectopic fat deposition in pancreas and pancreatic volume were calculated and compared in patients with diabetes versus healthy population Compared to healthy controls, patients with diabetes had significantly higher pancreatic MRI-PDFF (95% confidence interval difference 14.3-16.9, p value < 0.0001) and lower pancreatic volume (95% confidence interval difference - 30 to -24, p value < 0.0001) and these results remained consistent in multivariable-adjusted models including age, sex, BMI and liver fat.
