Abstract #1931

Evaluation of long-term exercise intervention on ectopic fat accumulation in high fat diet fed rats

Venkatesh Gopalan¹, Navin Michael², Kavita Kaur¹, Anantharaj Rengaraj¹, Jadegoud Yaligar¹, Sanjay Kumar Verma¹, Giang Thi Thu Le¹, Adaikalavan Ramasamy², Suresh Anand Sadananthan², Karthik Babu Mallilankaraman³, and S Sendhil Velan^1,3

¹Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ²Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ³Department of Physiology, National University of Singapore, Singapore, Singapore

In this study, we evaluated the effect of long-term exercise in reversing the effects of an obesogenic environment on pathogenic fat accumulation and insulin sensitivity in high fat diet fed rats. Bias-corrected effect size (Hedge’s g, 95% CI), of IHL, IMCL, triglycerides, cholesterol, leptin and Matsuda Index after 12 weeks intervention was determined between high fat diet (HFD), Control, HFD + Exercise groups. The long term exercise intervention improved the insulin sensitivity in high fat diet fed rats by reducing all fat depots, triglycerides, and leptin.

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