Abstract #1908

Small field of view 2D spatially selective RF excitation diffusion tensor (DTI) imaging of the kidneys: initial experience in healthy controls and patients with Type 2 diabetes

Julia Williams¹, Yuliya Perchyonok^1,2, Leonid Churilov^2,3, Emma Hornsey¹, Lucy McKenna¹, Niloufar Torkamani^1,2, Daniel Staeb⁴, Julie Smith¹, Elif Ekinci^1,2, Artem Mikheev⁵, Henry Rusinek⁵, and Ruth P Lim^1,2

¹Austin Health, Heidelberg, Australia, ²The University Melbourne, Melbourne, Australia, ³The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ⁴Siemens Healthcare Pty Ltd, Melbourne, Australia, ⁵New York University School of Medicine, New York, NY, United States

Fractional anisotropy (FA) and mean diffusivity (MD) derived from diffusion tensor imaging (DTI) are promising for assessing subclinical changes in diabetic kidney disease (DKD). However, renal echo planar DTI can be challenging due to susceptibility artefacts, which can be mitigated by a small field of view (FOV) 2D spatially selective RF excitation. We report initial experience at 3T in 9 controls and 4 diabetic patients, finding high inter-reader agreement for cortical and medullary FA and MD, and significantly lower medullary and cortical FA in patients compared to controls. Small FOV DTI is a feasible non-invasive method of DKD assessment/ monitoring.

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