The role of high-resolution apparent diffusion coefficient histogram analysis in evaluating tumor response of locally advanced rectal cancer after neoadjuvant chemeradiotherapy

This study analyzed both pre- and post-chemoradiotherapy ADC map of rectal cancer to evaluate tumor regression by using histogram metrics. The ADC map was generated from high-resolution DWI using read-out segmented echo-plannar imaging sequence, with less distortion and susceptibility artifact. Our study did not find any added value of histogram metrics of ADC map in assessing tumor response, and post-treatment mean ADC value alone may be enough in clinical.