Abstract #1668

Usefulness of amide proton transfer imaging in the evaluation of autoimmune pancreatitis activity

Yoshihiko Fukukura¹, Yuichi Kumagae¹, Hiroto Hakamada¹, Hiroaki Nagano¹, Takashi Iwanaga², Jochen Keupp³, Yuta Akamine⁴, and Takashi Yoshiura¹

¹Kagoshima University Graduate School of Medical and Dental Sciences, kagoshima, Japan, ²Department of Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, ³Philips GmbH Innovative Technologies Research Laboratories, Hamburg, Germany, ⁴Philips Electronics Japan, Tokyo, Japan

This study focused on the potential of amide proton transfer (APT) MR imaging at 3.0T as an objective imaging biomarker in patients with autoimmune pancreatitis (AIP). Correlation of serum immunoglobulin G4 (IgG4) levels with APT SI, the apparent diffusion coefficient (ADC) values or the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was evaluated in eleven patients with AIP. Our results showed a significant positive correlation between serum IgG4 levels and APT signal intensity (SI). Therefore, APT imaging might be useful for monitoring AIP activity.

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