Abstract #1632

Quantitative comparison of luminal water imaging with DWI for characterization of prostate cancer aggressiveness: early experience

Stefanie Hectors^1,2, Daniela Said^1,2, Jeffrey Gnerre^1,2, Ashutosh Tewari³, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Luminal water imaging (LWI) is an emerging technique for noninvasive characterization of prostate cancer (PCa) aggressiveness. The goal of our ongoing study is to compare the diagnostic performance of LWI to DWI for assessment of PCa aggressiveness. We observed that the luminal water fraction (LWF) from LWI showed high diagnostic performance for differentiation between Grade Group (GG) 2 (i.e. Gleason 3+4) and GG 3 and higher (i.e. Gleason 4+3 and higher) cancers (AUC=0.86), while ADC showed an AUC of 0.62. These initial results suggest additional value of LWI for PCa characterization, which will be verified in a larger cohort.

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