Abstract #1621

Variable Flip Angle T1 Consistency with and without Compensating for B1+ inhomogeneity in 3T Prostate MRI

Xinran Zhong^1,2, Sepideh Shakeri¹, Dapeng Liu¹, James Sayre¹, Steven S. Raman¹, Holden H. Wu^1,2, and Kyunghyun Sung^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States

Reliable pre-contrast T₁ estimation is crucial for quantitative DCE MRI. Variable flip angle is widely used for pre-contrast T₁ measurements and is sensitive to B₁⁺ inhomogeneity. Although various B₁⁺ techniques have been proposed, the application of B₁⁺ compensation is not widely accepted yet. In this study, by evaluating T₁ intra-scanner and inter-scanner consistency with and without B₁⁺ compensation, we confirmed the necessity to perform B₁⁺ compensation and a B₁⁺ estimation method named reference region variable flip angle (RR-VFA) is recommended due to its consistent T₁ estimation and wide availability.

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