We have developed a series of 3D UTE-Cones MRI techniques for quantitative assessment of all major tissues in the knee joint. Continuing improvements in scan time will facilitate their clinical use, but it remains unclear how acceleration affects quantification. This study focused on the effects of stretching sampling windows on quantitative UTE biomarkers in cadaveric human knee joint tissues. We found that extending sampling windows results in vastly reduce scan time without adverse effects on quantitative accuracy of T1, AdiabaticT1ρ, macromolecular fraction and MTR of articular cartilage, menisci, tendons and ligaments in the knee joint.
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