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Abstract #1331

gagCEST effect strongly depends on GAG molecular composition

Emma Olsson1, Pernilla Peterson1, André Struglics2, Michael Gottschalk3, Patrik Önnerfjord4, and Jonas Svensson1,5

1Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden, 2Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, 3Lund University Bioimaging Center, Lund University, Lund, Sweden, 4Rheumatology and Molecular Skeletal Biology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, 5Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden

gagCEST has been suggested as a method for in vivo evaluation of cartilage GAG content. The main type of GAG in cartilage is chondroitin sulfate (CS), most commonly CS-A and CS-C. Validation of gagCEST have mostly been performed using CS-A but the main type in mature human articular cartilage is CS-C. In this study we evaluate the gagCEST effect from GAG in different forms. Our results indicate that mainly CS-A is contributing to gagCEST effect in cartilage, while no or little effect is seen from CS-C. gagCEST may therefore not correctly reflect the GAG content of human articular cartilage.

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