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Abstract #1303

HIGH RESOLUTION IMAGING AND QUANTIFICATION OF VASCULATURE WITHIN CORTICAL BONE POROSITY USING DCE-MRI AND HR-pQCT

Matthew Gibbons1, Po-hung Wu1, Sarah Foreman1, Misung Han1, Roland Krug1, Jing Liu1, Thomas Link1, and Galateia Kazakia1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Cortical bone porosity is a major determinant of bone strength. However, the causes of pathological pore growth are not well understood. The prevalence of blood vessels or marrow fat in pores may serve as an indicator for vessel- or marrow-driven processes. We present an algorithm to combine high resolution CT for pore identification and dynamic contrast enhanced MRI for blood vessel identification. Using this algorithm, imaged vessels are associated with specific pores and pore content is quantified.

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