Abstract #1292

An investigation of the relationship between type II collagen degradation products and MRI features of damage in knee osteoarthritis patients

Franklyn A Howe¹, Vivian Ejindu², Christine Heron², Olakunbi Harrison³, Soraya Koushesh³, Lena Assi³, Anasuya Kuttapitiya⁴, Thomas R Barrick¹, and Nidhi Sofat³

¹Molecular & Clinical Sciences Research Institute, St George's, University of London, London, United Kingdom, ²St George's University Hospitals NHS Foundation Trust, London, United Kingdom, ³Institute of Infection & Immunity, St George's, University of London, London, United Kingdom, ⁴Great Ormond Street Hospital, London, United Kingdom

Knee osteoarthritis (OA) is a degenerative disease which produces pain and exhibits damage to cartilage, bone marrow and the development of synovitis. Biomarkers are needed to aid patient stratification for developing improved treatment strategies. We have investigated how type II collagen degradation products (CTX2), which are generated during OA, relate to MRI features of knee damage and patient reported pain. CTX2 was strongly related to synovitis and cartilage damage whereas reported pain was more strongly related to depression and BMI. CTX is thus complementary to pain scores as a marker of OA severity.

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