Chemical shift encoding-based water-fat MRI derived proton density fat fraction (PDFF) of muscles has been emerging as a surrogate marker for quantification of ectopic fat accumulation. Increased fatty deposits are a risk factor for metabolic and cardiovascular diseases. With skeletal muscle being the largest body compartment in adults, we are still at the beginning of understanding the functional consequences of these changes. The purpose of the present analysis was to investigate the gender- and age-related changes in PDFF of trunk musculature of healthy adults using chemical shift encoding-based water-fat MRI.
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