Abstract #1263

Creatine CEST at 3T following in magnet exercise shows differences in heart failure patients with preserved ejection fraction compared to healthy and hypertensive controls

Neil Wilson¹, Payman Zamani², Elizabeth Proto², Kevin D'Aquilla¹, Dushyant Kumar¹, Deepa Thakuri¹, Hari Hariharan¹, Shana McCormack³, Julio Chirinos², and Ravinder Reddy¹

¹CMROI, University of Pennsylvania, Philadelphia, PA, United States, ²Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, ³Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Exercise intolerance is a hallmark of heart failure. Here, we have shown for the first time that parameters derived from ROI-based analysis of creatine-weighted CEST signals following exercise can be used to distinguish HFpEF patients from HTN and healthy controls. Identifying these group differences is uniquely possible because CrCEST can measure muscle specific metabolism with high spatial resolution and sensitivity.

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