Prompt recognition the characteristics of extraocular muscles (EOMs) representing responding to intravenous methylprednisolone pulses (ivMP) is crucial for identifying optimal, patient-tailored treatment options in the era of personalized, precision medicine for thyroid-associated ophthalmopathy (TAO). This study attempts to predict the therapy response using the baseline histogram features of EOMs from volumetric T2 relaxion time (T2RT) texture analysis. Multivariate logistic regression analysis suggested that 90th and 95th percentile T2RT, skewness, entropy and inhomogeneity were significant predictors of ivMP response. Volumetric T2RT histogram analysis is a feasible and promising tool for predicting the response of ivMP therapy in patients with TAO.
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