Abstract #1237

Simultaneous 13N-Ammonia and gadolinium first-pass myocardial perfusion with hybrid PET-MR imaging: a clinical feasibility study.

Muhummad Sohaib Nazir¹, Sarah-May Gould¹, Xenios Milidonis¹, Eliana Reyes¹, Tevfik F. Ismail¹, Radhouene Neji^1,2, Sébastien Roujol¹, Jim O'Doherty¹, Hui Xue³, Sally Barrington¹, Reza Razavi¹, Paul Marsden¹, Peter Kellman³, Sven Plein^1,4, and Amedeo Chiribiri¹

¹Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Siemens Healthcare, Camberley, United Kingdom, ³National Heart, Lung and Blood Institute, Bethesda, MD, United States, ⁴Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom

Hybrid PET-MR imaging allows simultaneous measurement of myocardial blood flow (MBF) under identical physiological conditions. We sought to determine feasibility of simultaneous ¹³N-Ammonia PET and dynamic contrast-enhanced cardiovascular magnetic resonance (CMR) in healthy volunteers. ¹³N-Ammonia and gadolinium contrast were administered simultaneously during adenosine stress. Mean global stress MBF values for PET and CMR were 2.58 ± 0.11ml/g/min and 2.60 ± 0.47ml/g/min respectively. On a per territory basis, there was a moderate correlation (r = 0.63, p=0.03) and CMR underestimated PET MBF by 0.34ml/g/min (95% limits of agreement -0.49 to +1.18). Future studies in patients with CAD is warranted.

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