Abstract #1151

Chronic hepatic encephalopathy in early developing brain, neurometabolic changes differ depending on the age of disease onset, in vivo longitudinal 1H MRS study

Veronika Rackayova¹, Olivier Braissant², Valerie McLin³, and Cristina Cudalbu¹

¹CIBM, EPFL, Lausanne, Switzerland, ²Service of Biomedicine, Neurometabolic Unit, Lausanne University Hospital, Lausanne, Switzerland, ³Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

Chronic hepatic encephalopathy (CHE) due to chronic liver disease (CLD) causes irreversible cognitive deficits in children. We aimed to study possible differences in neurometabolic changes in rat model of CLD&CHE depending on the age of the disease onset (post-natal day 15 vs 21), using in-vivo ¹H-MRS. We showed differences in Gln, tCho, Lac, Asc, GSH and neurotransmitter concentrations between p15 and p21 pups during the evolution of the disease. These differences suggest that age of disease onset and its coincidence with neurodevelopmental processes play an important role and may result in different vulnerability to the disease depending on the age.

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