Post-transplant, lungs are clinically monitored using regular radiography and/or CT scans to detect rejection. We previously demonstrated that lactate-to-pyruvate ratio derived via hyperpolarized (HP) [1-13C]-pyruvate MRI is an earlier predictor of lung rejection than microCT in an orthotopic rat lung transplantation model. In this study, we imaged transplanted allogeneic lungs in a recipient rats with acquired immune tolerance to resolve the signal contribution of ischemia-reperfusion injury from that of tissue rejection. Transplanted rat lungs with acquired immune tolerance exhibit similar behavior to that of syngeneic lung transplants before abolishing their acquired tolerance.
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