Neglecting differences in compartmental transverse relaxation times when modeling diffusion MRI data may affect the accuracy of estimates for microstructural parameters. Here we propose a straightforward method for correcting the bias in the axonal water fraction (AWF), as calculated from the fiber ball white matter (FBWM) model, due to T2 differences between the intra-axonal and extra-axonal compartments. This correction scheme simply requires that one additional high b-value shell be acquired at a different echo time than for the standard dataset needed for FBWM. AWF values were found to be 16% lower, on average, after the T2 correction.
This abstract and the presentation materials are available to members only; a login is required.