Myelin is a key white matter compartment, but myelin water is beyond the detection of conventional diffusion MRI methods because of its short T2. Here we combine ultra-strong gradients and spiral readout to achieve very short echo times (TE=30ms) at very high diffusion weighting (b=6000s/mm^2), with the aim of achieving significant sensitivity to the diffusion of myelin water in the living human brain. We investigated the challenge of disentangling 3 distinct compartments – including the short T2 component from myelin.
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