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Abstract #1111

Objective lung-density quantification in neonatal bronchopulmonary dysplasia via ultrashort echo-time MRI, with comparison to clinical severity and reader scoring

Nara S Higano1,2,3, Robert J Fleck3,4,5, Andrew H Schapiro3,4,5, Andrew D Hahn6, Sean B Fain6,7, Melissa House3,5,8, Paul S Kingma3,5,8, and Jason C Woods1,2,3,4,5

1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital, Cincinnati, OH, United States, 2Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States, 3BPD Center, Cincinnati Children's Hospital, Cincinnati, OH, United States, 4Radiology, Cincinnati Children's Hospital, Cincinnati, OH, United States, 5Pediatrics, University of Cincinnati, Cincinnati, OH, United States, 6Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 7Radiology, University of Wisconsin - Madison, Madison, WI, United States, 8Neonatology and Pulmonary Biology, Cincinnati Children's Hospital, Cincinnati, OH, United States

Neonatal lung disease of prematurity (bronchopulmonary dysplasia, BPD) is a serious pulmonary condition. However, there is little understanding of the underlying structural pathologies or relationship to disease trajectories. Pulmonary MRI of neonatal BPD is an emerging research technique, with preliminary correlation to clinical outcomes, but assessment of parenchyma has been limited to manual radiological reads. We present quantitative lung-density measures in 55 patients from ultrashort echo-time (UTE) MRI, with strong correlation to clinical BPD severity and a current BPD reader scoring system. This technique distinguishes between patients with varying lung-density phenotypes, which in the future may help inform treatment strategies.

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