Meeting Banner
Abstract #1072

The Utility of MRI for Measuring Hematocrit in Fetal Anemia

Jiawei Xu1, An Qi Duan2, Davide Marini3, Johannes Keunen4, Sharon Portnoy5, John G Sled5,6,7, Brian W McCrindle3, John Kingdom4, Christopher K Macgowan5,7, and Mike Seed3

1Department of Physiology, University of Toronto, Toronto, ON, Canada, 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada, 3Division of Cardiology, Hospital for Sick Children, Toronto, ON, Canada, 4Division of Maternal-Fetal Medicine, Mount Sinai Hospital, Toronto, ON, Canada, 5Division of Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 6Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, 7Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

To determine the accuracy of MRI for estimating hematocrit in anemic fetuses, the current study compared MRI-estimated hematocrit against the gold-standard fetal blood sampling and Doppler assessment of the middle cerebral artery for peak systolic velocity (MCA-PSV). MRI-estimated hematocrit was calculated from T1 and T2 measurements of intrahepatic umbilical vein blood. MRI results correlated well with fetal blood sampling and had a higher specificity for predicting anemia than Doppler MCA-PSV. In conclusion, MRI is feasible and accurate for the detection of fetal anemia and may be used to confirm the need for blood transfusion when MCA-PSV is suggestive of anemia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract