The purpose of this study was to evaluate the need for a comprehensive description of the macromolecular baseline signal (MMBL), e.g. for MR fingerprinting and multidimensional fitting of MR spectra. Inherent J-evolution for certain signals as well as multi-component T2-decays can cause variance of the signal shape as function of TE that is not described in a mono-exponential decay model. Two methods are described to accommodate this signal behavior when fitting a 2DJ-Inversion-Recovery dataset. In addition, the MMBLs for different TEs, as well as resulting metabolite contents, T1s and T2s with the conventional and alternative methods are reported.
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