Abstract #1048

Myeloarchitectonic mapping of cortical gray matter with 3D inhomogeneous magnetization transfer (ihMT)

Fanny Munsch¹, Gopal Varma¹, Manuel Taso¹, Olivier M Girard², Arnaud Guidon³, Guillaume Duhamel², and David C Alsop¹

¹Division of MRI research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²CRMBM, Aix Marseille Univ, CNRS, Marseille, France, ³Global MR Applications and Workflow, GE Healthcare, Boston, MA, United States

Advances in inhomogeneous magnetization transfer (ihMT) imaging have enabled improved volumetric imaging of gray matter. We performed a cortical surface-based analysis of the ihMT ratio (ihMTR) and the inverse ihMT ratio (ihMTR_inv) to investigate the distribution of myelin in cortical gray matter. IhMT MRI, and especially ihMTR_inv, displayed regional differences in cortical myelination, in agreement with postmortem studies. These findings support the myelin sensitivity and specificity of ihMTR_inv and its use for gray matter characterization.

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