Liver T1 measurements can be used to characterise liver disease but are also sensitive to physiologically normal liver changes. In this work, a set of metabolic interventions were performed to assess the effect of liver glycogen concentration and body hydration status on liver shMOLLI T1 measurements in healthy volunteers. Glycogen showed an in vivo relaxivity in keeping with literature phantom data and hydration status showed a smaller effect. Our results will impact the way T1 measurements of participants with impaired glycogen storage are interpreted, as well as instructions given to participants before their scans.
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