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Abstract #1020

Repeatability and Reproducibility of Confounder-Corrected R2* as a Biomarker of Liver Iron Concentration: Interim Results from a Multi-Center, Multi-Vendor Study at 1.5T and 3T

Diego Hernando1,2, Ruiyang Zhao1,2, Valentina Taviani3, Mounes Aliyari Ghasabeh4, Li Pan5, Qing Yuan6, Stefan Ruschke7, Dimitrios C. Karampinos7, Xiaodong Zhong8, Ryan J. Mattison9, Ihab R. Kamel4, Ivan Pedrosa6, Shreyas Vasanawala10, Takeshi Yokoo6,11, and Scott B. Reeder1,2

1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, 4Radiology, The Johns Hopkins University, Baltimore, MD, United States, 5Siemens Healthineers, Baltimore, MD, United States, 6Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Radiology, Technical University of Munich, Munich, Germany, 8Siemens Healthineers, Los Angeles, CA, United States, 9Medicine, University of Wisconsin-Madison, Madison, WI, United States, 10Radiology, Stanford University, Palo Alto, CA, United States, 11Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

R2* mapping has the potential to provide rapid and reliable quantification of liver iron concentration. Importantly, previous studies have demonstrated that by correcting for relevant confounding factors (eg: noise floor effects and fat) R2* mapping is highly insensitive to the presence of these confounders. However, the repeatability and reproducibility of confounder-corrected R2* across multiple sites and vendors remains unknown. This abstract reports interim results from a multi-center, prospective, NIH-sponsored liver iron quantification study. Our results suggest excellent repeatability and reproducibility of confounder-corrected R2* for liver iron quantification in patients, across four centers, three vendors and at both 1.5T and 3T.

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