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Abstract #0958

The alteration of white matter tract of patients with Parkinson's disease combined with the changes in tract-connected gray matter : a longitudinal report

Shi-Ming Wang1, Sung-han Lin1, Chih-Chien Tsai1, Yi-Hsin Weng2, Yao-Liang Chen3, Xiang-An Zhao1, and Jiun-Jie Wang1

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan, 2Neurology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 3Radiology, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan

Parkinson's disease (PD) is a progressive nervous system disorder as a result from the loss of cell in basal ganglia. Fixel-Based Analysis can qualify the fibre density and fibre-bundle cross-section in the nerve fibre. Further, gray matter degeneration was determined by using ROI-based Analysis to investigate Mean Diffusivity (MD) changes. Therefore, the current study proposed to investigate the structural connectivity of atrophy cortical regions in the PD patients with axonal injury over a period of 2 years.

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