This study shows the presence of a distinctive anatomical backbone network in early Parkinson’s Disease (PD) involving cortical and subcortical regions that are known to be involved in various stages of PD, including early PD. Impaired network segregation and rich-club measures were further found within this backbone network in PD which were associated with disease duration. We hope that by identifying a set of core abnormalities in PD structural connectivity, this will permit improved ability to understand structural-network related disease progression and also to understand changes in these core structural connectivity measures with disease-modifying therapies as they emerge.
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