Abstract #0948

Using an AC/DC Coil to Improve the Line Width and Lipid Suppression for measuring 2HG in Glioma Patients at 3T

Bernhard Strasser¹, Nicolas S. Arango², Jason P. Stockmann^1,3, Borjan Gagoski^4,5, Bijaya Thapa¹, Xianqi Li¹, Wolfgang Bogner⁶, Julia Small⁷, Daniel P. Cahill⁷, Tracy T. Batchelor⁸, Jorg Dietrich⁸, Lawrence L. Wald¹, Jacob White², Elfar Adalsteinsson^2,9, and Ovidiu C. Andronesi¹

¹Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁶Department of Radiology, Medical University of Vienna, Vienna, Austria, ⁷Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States, ⁸Department Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, United States, ⁹Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

An AC/DC 32-channel coil, which can detect signal while simultaneously alter the B0-field, was used to improve lipid inversion and the spectral linewidth for measuring 2HG. Two patients and two volunteers were measured with a spiral-based 3D sequence once with the standard scanner shim only, and once with the additional shimming of the integrated B0/Rx coil. Data quality was strongly improved, leading to improved 2HG-detection in one patient, and a decreased variability of 2HG in tumor-void areas. This can reduce the likelihood of false-positive 2HG detection. Quantification of other metabolites was additionally improved by the AC/DC shim.

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