Cranial radiation therapy (CRT) is an effective brain cancer treatment but many patients exhibit cognitive deficits over time. We studied these deficits in adolescent and young adult survivors of pediatric brain cancer with prior CRT using white matter graph network analysis. Executive function and working memory performance were correlated with structural connectivity metrics. Global integration and segregation metrics were associated with neurocognitive deficits, as well as connectivity at domain-specific regions. Our results support past findings of CRT’s negative cognitive effects and suggest that they are driven through structural changes in brain white matter
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