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Abstract #0870

IVIM Analysis in Response Evaluation of Osteosarcoma Treated with Neoadjuvant Chemotherapy: Correlation with Histopathological Necrosis

Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Kedar Khare3, Raju Sharma2, Sameer Bakhshi4, and Amit Mehndiratta1,2

1Center for Biomedical Engineering, Indian Institute of Technology, Delhi, India, New Delhi, India, 2Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, 3Department of Physics, Indian Institute of Technology, Delhi, India, New Delhi, India, 4Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India

Histological necrosis is the current gold standard for response evaluation in osteosarcoma treated with neoadjuvant chemotherapy (NACT). However it is applicable only after tumor resection on completion of NACT. Thus, a non-invasive early marker of NACT response is desirable. We performed NACT response prediction and evaluation using Intra-voxel Incoherent Motion (IVIM) Diffusion weighted MRI and histogram analysis. IVIM parameters and its histogram analysis revealed clinically useful information in characterizing and predicting chemotherapy response to Osteosarcoma.

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