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Abstract #0854

Low extracellular acidification in 1p/19q co-deleted gliomas confirmed using pH-weighted amine CEST-EPI, T2 relaxometry, and amino acid PET

Jingwen Yao1,2,3, Ararat Chakhoyan1,3, Catalina Raymond1,3, Noriko Salamon3, Linda Liau4,5, Phioanh Nghiemphu6, Albert Lai5,6, Whitney Pope3, Timothy Cloughesy6, and Benjamin Ellingson1,2,3,5,7,8

1Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 2Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 5UCLA Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 6Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 7Physics and Biology in Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 8Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

The 1p/19q co-deletion in gliomas is associated with better response to therapies and better patient prognosis. In this study, we demonstrate that 1p/19q co-deleted gliomas are less acidic than gliomas with intact 1p/19q using a combination of pH-sensitive amine CEST-EPI, T2 relaxometry, and 18F-FDOPA PET. Results suggest amine CEST-EPI may serve as a quick non-invasive imaging biomarker for identifying 1p/19q co-deleted tumors. Our results also support the hypothesis that the better prognosis and higher sensitivity to treatment of 1p/19q co-deleted gliomas may be related to less acidity in tumor microenvironment.

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