The accuracy of MRI based glomerular filtration rate (GFR) measurements using the standard Cartesian VIBE DCE-MRI is limited by motion and temporal resolution. Instead, we use motion-robust high temporal resolution radial VIBE for DCE-MRI for accurate estimation of GFR. We optimize its temporal resolution and compressed sensing reconstruction temporal regularization parameters to obtain an accurate arterial input function peak while reconstructing good quality images. We also developed a fully automated segmentation and tracer kinetic model-fitting pipeline to compute MRI-GFR. We assessed the accuracy of proposed technique to measure GFR by comparing MRI-GFR to GFR from 99mTcDTPA nuclear medicine study (NMGFR).
This abstract and the presentation materials are available to members only; a login is required.