Time-encoded PCASL angiography is an attractive method for deriving some, or all, of the desired temporal information from the PCASL preparation rather than a dynamic readout. Higher flip-angles can then be used for the remaining excitation pulses in the readout, increasing the signal-to-noise ratio of the angiograms.
However, use of constant flip angles across all excitations leads to abrupt signal changes between images constructed from different time-encoding blocks. A variable flip-angle scheme is presented, which maintains a constant signal across all excitations, removes these discontinuities and ensures optimal signal levels across all images.
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