3D whole-brain ASL is typically performed using either Stack-of-Spirals FSE or GRASE. However, those readouts suffer from significant image blurring and off-resonance sensitivity. Hence, Cartesian encoding would be highly desirable because of its robustness and high image quality, but acquisition times remain prohibiting. We therefore report the implementation of an accelerated 3D-FSE sequence using variable-density Poisson-disk undersampling to provide redundant k-space center sampling while varying the outer pseudo-random sampling and Parallel-Imaging Compressed-Sensing reconstruction to provide high quality high-resolution whole brain ASL perfusion images.
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