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Abstract #0824

MEMRI Can Quantify Myocardial Infarct Size Earlier Than LGE-MRI

Nur Hayati Jasmin1,2, May Zaw Thin1, Valerie Taylor1, Christopher S Pope1, Mark F Lythgoe1, Sean Davidson3, and Daniel J Stuckey1

1Division of Medicine, Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2School of Medical Imaging, Universiti Sultan Zainal Abidin, Terengganu Darul Iman, Malaysia, 3Hatter Cardiovascular Institute, University College London, London, United Kingdom

Late gadolinium enhanced MRI (LGE-MRI) is an established method for quantification of infarct size after myocardial infarction but is non-specific and reflects the increased membrane rupture and extracellular volume (ECV) that occurs several hours after myocardial infarction. Manganese (Mn2+) is an efficient intracellular MR contrast agent, which acts as an analogue of Calcium (Ca2+) and can provide information on cell viability. The present study shows that manganese-enhanced MRI (MEMRI) can quantify the final infarct size earlier than LGE-MRI.

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