Abstract #0783

Heartbeat-to-Heartbeat Quantitative Myocardial Oxygenation Imaging within a Single Breath-Hold using a Combined Gradient Echo-Spin Echo EPI (GESE-EPI) Sequence in Patients with Hypertension

Maaike van den Boomen^1,2, Gert Jan H. Snel², Christopher Nguyen^1,3,4, Mary Kate Manhard¹, David Sosnovik^1,3,4, Rudi A.J.O. Dierckx^2,5, Ciprian Catana^1,6, David Izquerdo-Garcia^1,6, Bruce R. Rosen^1,6, Niek H.J. Prakken², Ronald J.H. Borra^5,7, and Kawin Setsompop^1,6,8

¹A.A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, ³Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ⁴Medicine, Harvard Medical School, Boston, MA, United States, ⁵Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands, ⁶Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁷Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland, ⁸Division of Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

Dynamic Cardiac BOLD imaging techniques can suffer from signal variabilities due to changes in heartrate during a breath-hold. We demonstrate that a 2-echo-GESE-EPI sequence can provide T₂- and T₂^*-weighted images simultaneously per heartbeat, but the dynamic changes in these images represent physiological effects mixed with heartrate changes. We then proposed a 5-echo-GESE-EPI for dynamic T₂- and T₂^*-mapping per heartbeat as a readout for myocardial oxygenation. These dynamically acquired T₂- and T₂^*-values were demonstrated to increase over the time of a breath-hold for healthy volunteers, while shown to remain constant and even reverse in hypertension patients.

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