Abstract #0718

Hyperpolarized [1-13C]Pyruvate MRSI at 48 hrs post anti-VEGF Treatment Predicts Response in C6 Glioma Implanted Rats

Keshav Datta^1,2, Mette Hauge Lauritzen¹, Milton Merchant³, Taichang Yang³, Shie-Chau Liu¹, Ronald Watkins¹, Ralph Hurd¹, Lawrence Recht³, and Daniel Mark Spielman^1,2

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering, Stanford University, Stanford, CA, United States, ³Neurology, Stanford University, Stanford, CA, United States

Using a bolus injection of hyperpolarized [1-¹³C]Pyruvate, we show that measurement of the resulting ¹³C-Lactate to ¹³C-Bicarbonate ratio 48-hours post-treatment with anti-angiogenic drug Bevacizumab (Bev20) predicts survival in a C6-Glioma rat model. A positive correlation of Lac/Bic with tumor growth rate further supports our hypothesis that the effect of the drug in survivors is to reverse the tumor Warburg metabolic phenotype necessary to support rapid proliferation.

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