Abstract #0705

Time-efficient fully 3D non-Cartesian dynamic contrast-enhanced free-breathing MRI of the pelvis with an ultrashort TE cones trajectory

Signy Holmes¹, Frank Ong², Michael Lustig², Ryan Brunsing¹, Vipul R Sheth¹, Marcus T Alley¹, Michael Carl³, John M Pauly⁴, Joseph Y Cheng¹, and Shreyas S Vasanawala¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, ³Applied Science Laboratory, GE Healthcare, San Diego, CA, United States, ⁴Electrical Engineering, Stanford University, Stanford, CA, United States

A 3D cones k-space trajectory with golden angle ordering was developed along with a multiscale low rank reconstruction for dynamic contrast enhancement with ultrashort echo time (DCE-UTE) and with fast image reconstruction time. With IRB approval and informed consent the sequence was tested in 21 consecutive subjects referred for 3T contrast-enhanced pelvic MRI. For comparison, a Cartesian DCE SPGR sequence with golden angle radial k-space ordering, soft-gated self navigation, and low rank reconstruction (DCE-SPGR) served as case controls. DCE-UTE performed significantly better than DCE-SPGR in delineation of anatomic structures (p=0.004) and overall perceived image quality (p=0.003). These results indicate a 3D fully noncartesian DCE-UTE sequence and reconstruction improves image quality in pelvic DCE.

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