Region-growing (RG) is one of most computationally efficient fat-water separation methods, which exploits B0 smoothness assumption for separation with improved accuracy. However, practical robustness of RG method is majorly limited by low accuracy of initial seeded B0 values, which are problematic to select due to competing off-resonance from fat. Recently, it was demonstrated that insensitivity of fat to magnetization transfer (MT) preparation can be utilized to produce fat-insensitive B0 field priors. Here, we present a modified RG method that exploits this phenomenon to solve problems of seeding and stability of the original method and to attain robust F/W separation.
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