Axon diameter mapping using diffusion MRI in the rat corpus callosum was validated using confocal microscopy with a staining for neurofilaments. When confounding factors such as extra-axonal water and dispersion are addressed, the effective MR axon radii are in good quantitative agreement with histology. However, using MRI, we are limited to the estimation of a single metric representing the entire distribution, which has shown to be dominantly sensitive to the largest axons in the voxel volume of interest.
This abstract and the presentation materials are available to members only; a login is required.