Abstract #0635

Cortical thickness is a sensitive biomarker for characterizing the gray matter abnormities in neonates with mild white matter injury

Miaomiao Wang¹, Jing Xia², Jian Chen², Xianjun Li¹, Congcong Liu¹, Li Wang², XiaoCheng Wei³, Gang Li², Dinggang Shen², and Jian Yang¹

¹Department of Diagnostic Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, ²Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina, NC, United States, ³MR Research China, GE Healthcare, Beijing, China

White matter injury is common in neonates. The most common punctate white matter lesions (PWML) can disappear along with time and are easily missed diagnosis, but quantitative measurements may find more subtle alterations. Since DTI is not sensitive to detect the white-matter microstructural changes in mild PWML, alterations in gray-matter (GM) may provide additional knowledge for predicting prognosis. This study aims to quantitatively assess alterations of GM in neonates with mild PWML. Compared with controls, a significant reduction of cortical volume is observed in neonates with mild PWML, and cortical thickness is a sensitive biomarker for characterizing the GM abnormalities.

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