Intracranial Pulse Wave Velocity in Alzheimer’s Disease using Flow Encode Split and Low Rank Reconstructed 4D Flow MRI
Leonardo A Rivera-Rivera1, Sterling C Johnson2, Chuck Illingworth2, and Kevin M Johnson1,3
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 3Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States
Experimental, clinical and epidemiologic evidence shows vascular factors play a role in Alzheimer’s Disease (AD); however, whether AD has a basis in vascular diseases is controversial. Intracranial pulse wave velocity (PWV) is a potential parameter that can probe arterial stiffness changes in AD, but is technically demanding due to requirements of high temporal resolution. In this study, we investigated high temporal resolution 4D flow using 3D radial sampling, low-rank regularization and interleaved encoding splitting for intracranial PWV estimates. Preliminary results from 26 subjects showed an increased intracranial PWV in an AD group when compared to controls.
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