Laminar fMRI at ultra-high field is typically carried out using the BOLD contrast. Despite its unrivalled sensitivity, the BOLD contrast is limited in its spatial specificity (e.g. due to intracortical ascending and pial veins). Alternatively, the regional change in cerebral blood flow (CBF), is a quantitative measure directly related to neuronal activation. However, CBF fMRI with high spatial resolution is challenging due to the relatively lower SNR. Building on previous work, we demonstrate for the first time, sub-millimetre spatial resolution simultaneous CBF and BOLD acquisition using arterial spin labelling (ASL) for laminar fMRI at 7T.
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