Abstract #0603

First-in-human: tackling the hypoxic challenge in breast cancer with advanced MRI

Katja Pinker-Domenig¹, Barbara Bennani-Baiti ¹, Thomas Helbich¹, Max Zimmermann², Pascal Baltzer¹, Paola Clauser¹, Pangiotis Kapteas¹, Zsuzsanna Bago-Horvath³, Peter Dubsky⁴, Rupert Bartsch⁵, and Andreas Stadlbauer²

¹Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany, ³Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁴Department of Surgery, Medical University of Vienna, Vienna, Austria, ⁵Department of Internal Medicine, Medical University of Vienna, Vienna, Austria

To develop a novel MRI approach for the non-invasive assessment of hypoxia and neovascularization in benign and malignant breast tumors and to provide insights into the intratumoral heterogeneity of breast cancer. 76 patients with a BI-RADS 4/5 lesion underwent 3T MRI of the breast with Vascular Architecture Mapping (and quantitative Blood Oxygenation Level Dependent (qBOLD) imaging. Our approach demonstrated that breast cancer consumes more oxygen and is more hypoxic and neovascularized than benign tumors. This non-invasive approach can be easily integrated in a diagnostic MRI protocol and has the potential to improve tumor characterization and facilitate tailored breast cancer treatment.

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