Radiomics has been studied as imaging biomarker for quantifying tumor characteristics non-invasively. In this study, we sought to evaluate the relationship between radiomics features of PET/MRI and its response towards neo-adjuvant chemotherapy (NAC). 26 females with newly diagnosed breast cancer underwent PET/MRI. Radiomics features were extracted from the PET/MRI images. Using the radiomics features, the group was then subdivided into three groups using unsupervised clustering. Different pathology response towards NAC was found among the groups, hence, showing there might be some associations among PET/MRI radiomics features and pathology response to NAC in breast cancer.